The expression of Nrf2 and Keap1 in laryngeal carcinoma and its clinical indication / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1148-1151, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-747217
ABSTRACT
OBJECTIVE@#To investigate the role of Keap1-Nrf2-ARE pathway in laryngeal carcinoma occurrence and development.@*METHOD@#Thirty-five laryngeal carcinoma samples and para-carcinoma tissues were taken from the patients who accepted operation treatment in our hospital from Feb 2012 to Sep 2013. The expression levels of Nrf2 and Keap1 were detected in 35 cases of laryngeal carcinoma with SP immunohistochemical methods. The data were analyzed by the SPSS 13.0 statistical software.@*RESULT@#The expression of Nrf2 in the 35 cases of laryngeal carcinoma was 77.14%, which in the para-carcinoma tissues was 8.57%, the difference between these two groups was statistically significant (P 0.05).@*CONCLUSION@#Keap1-Nrf2-ARE pathway may play an important role in progression of laryngeal squamous cell carcinoma.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Carcinoma de Células Escamosas
/
Biomarcadores de Tumor
/
Neoplasias Laríngeas
/
Péptidos y Proteínas de Señalización Intracelular
/
Factor 2 Relacionado con NF-E2
/
Proteína 1 Asociada A ECH Tipo Kelch
/
Carcinoma de Células Escamosas de Cabeza y Cuello
/
Neoplasias de Cabeza y Cuello
/
Metástasis Linfática
/
Metabolismo
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2015
Tipo del documento:
Artículo
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