Expression and clinical significance of human nuclear distribution C in nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 71-73, 2011.
Artículo
en Chino
| WPRIM
| ID: wpr-747424
ABSTRACT
OBJECTIVE@#To investigate the expression and clinical significance of human nuclear distribution (hNudC) in nasopharyngeal carcinoma (NPC).@*METHOD@#Immunohistochemical and western blot method were used to determine the expression of human nuclear distribution C in 80 cases of NPC and 30 cases of chronic inflammation of nasopharyngeal mucosa. The amounts of positive cells were analyzed . The relationship between the gene expression and clinic pathological features was analyzed too.@*RESULT@#The positive expression rate of human nuclear distribution C in NPC was 83.75%, which was higher than that in chronic inflammation of nasopharyngeal mucosa 23.33% (P < 0.05). The expression of human nuclear distribution C was positively correlated with the clinic pathological stages in NPC (P < 0.05), and positive expression rate of hNudC protein was increased with the progress of NPC clinical stage (P < 0.05).@*CONCLUSION@#Human nuclear distribution C is found to be closely associated with cell malignant hyperplasia. This protein is important indicators to predict the progression of patients.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Proteínas Nucleares
/
Carcinoma de Células Escamosas
/
Neoplasias Nasofaríngeas
/
Proteínas de Ciclo Celular
/
Metástasis Linfática
/
Metabolismo
/
Estadificación de Neoplasias
Tipo de estudio:
Estudio pronóstico
Límite:
Adulto
/
Anciano
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2011
Tipo del documento:
Artículo
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