Clinical significance of miRNA-204 in nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1780-1782, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-747632
ABSTRACT
OBJECTIVE@#To investigate the expression of miRNA-204 in patients with NPC and to analyze the as- sociation of the expression with the cIinicopathologicaI features and prognosis.@*METHOD@#The expression levels of miRNA-204 in 50 patients with NPC and 40 patients with nasopharyngeal chronic inflammation were detected by using stem-loop real-time reverse transcription-polymerase chain reaction RT-PCR. Analysis of the relationship between microRNA and prognosis by Kaplan-Meier method.@*RESULT@#Expression levels of miRNA-204 were down- regulated in patients with NPC as compared with patients with nasopharyngeal chronic inflammation (P < 0.05). The expression of miRNA-204 was associated with EBV infection, differentiation, lymphatic metastasis and TNM stages (P < 0.05). Low miRNA-204 expression was significantly correlated with shorter overall survival (P < 0.05) of NPC.@*CONCLUSION@#The downregulation of miRNA-204 expression has related with disease progression and miRNA-204 can serve as a potential therapeutic target for NPC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Carcinoma
/
Regulación hacia Abajo
/
Nasofaringe
/
Neoplasias Nasofaríngeas
/
Progresión de la Enfermedad
/
MicroARNs
/
Reacción en Cadena en Tiempo Real de la Polimerasa
/
Carcinoma Nasofaríngeo
/
Metástasis Linfática
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2014
Tipo del documento:
Artículo
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