The Effect of Nerve Growth Factor on Corneal Sensitivity after Laser in Situ Keratomileusis

ABSTRACT

PURPOSE: To determine if topically administered nerve growth factor (NGF) plays a role in accelerating the recovery of corneal sensitivity after laser in situ keratomileusis (LASIK). METHODS: A prospective double-masked study comparing the effect of topical NGF or balanced salt solution on corneal sensitivity after LASIK in rabbits was performed. Pre- and postoperative corneal sensitivity was assessed using the Cochet-Bonnet esthesiometer. RESULTS: Eyes that were treated with topical NGF demonstrated an earlier and faster recovery of corneal sensitivity after LASIK (p=0.0071). A statistically significant difference in corneal sensitivity was found between the topical NGF and control group at the postoperative time points of 2 weeks (p=0.0098), 3 weeks (p=0.0309), and 4 weeks (p=0.0276). CONCLUSIONS: Our results suggest that topically administered NGF plays a significant role in accelerating corneal reinnervation after LASIK.