Expression of phosphofructokinase 1 protein and it's enzyme activity on nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
; (24): 1455-1457, 2015.
Article
en Zh
| WPRIM
| ID: wpr-747828
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE@#The aim of this study is to investigate the expression of phosphofructokinase 1 and it's enzyme activity in nasopharyngeal carcinoma biopsy samples.@*METHOD@#Sixty-one biopsy samples were detected, including 41 tissues from patients with nasopharyngeal carcinoma as experimental group and 20 tissues from patients with chronic nasopharyngitis as control group. Phosphofructokinase 1 protein was detected by Western blot and it's enzyme activity was detected.@*RESULT@#It was observed that the expression levels of phosphofructokinase 1 protein and it's enzyme activities in the experimental group were higher than that in the control group (P < 0.01). In the experimental group, the expression levels of phosphofructokinase 1 protein and it's enzyme activities in patients with lymph node metastasis were higher than that in patients without lymph node metastasis (P < 0.01).@*CONCLUSION@#Phosphofructokinase 1 may be a marker in occurrence and metastasis of nasopharyngeal carcinoma.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Patología
/
Biopsia
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Carcinoma
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Biomarcadores de Tumor
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Estudios de Casos y Controles
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Neoplasias Nasofaríngeas
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Nasofaringitis
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Fosfofructoquinasa-1
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Carcinoma Nasofaríngeo
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Metástasis Linfática
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2015
Tipo del documento:
Article