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The expression of IL-23 in nasal mucosa of allergic rhinitis patients and its significance / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 638-640, 2010.
Artículo en Chino | WPRIM | ID: wpr-747938
ABSTRACT
OBJECTIVE@#To investigate the expression of interleukin (IL)-23 in the nasal mucosa of allergic rhinitis patients and its significance.@*METHOD@#mRNA and protein expression of IL-23 in inferior turbinate mucosa from 12 allergic rhinitis patients and 11 control patients was measured by means of real-time RT-PCR and immunohistochemistry, respectively.@*RESULT@#IL-23p19 mRNA relative expression level in nasal mucosa was significantly increased in allergic rhinitis patients compared with normal controls (P < 0.01). Immunohistochemical staining demonstrated that IL-23 protein was mainly expressed by infiltrating inflammatory cells in lamina propria and there was increased number of IL-23 positive cells in allergic rhinitis patients in comparison with normal controls. Correlation analysis showed that the mRNA and protein expression level of IL-23 was significantly positively correlated with the number of the inflammatory cells (r = 0.678 and 0.644, respectively; both P < 0.01) and the degree of subepithelial collagen deposition (r = 0.834 and 0.721, respectively; both P < 0.01). IL-23p19 mRNA relative expression level in nasal mucosa was significantly decreased in allergic rhinitis patients who used glucocorticoids compared with controls (P < 0.01).@*CONCLUSION@#IL-23 may contribute to the chronic inflammation and airway remodelling in allergic rhinitis.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estudios de Casos y Controles / Rinitis Alérgica Perenne / Alergia e Inmunología / Interleucina-23 / Inflamación / Metabolismo / Mucosa Nasal Tipo de estudio: Estudio observacional Límite: Adolescente / Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estudios de Casos y Controles / Rinitis Alérgica Perenne / Alergia e Inmunología / Interleucina-23 / Inflamación / Metabolismo / Mucosa Nasal Tipo de estudio: Estudio observacional Límite: Adolescente / Adulto / Femenino / Humanos / Masculino Idioma: Chino Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Año: 2010 Tipo del documento: Artículo