Expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 337-340, 2010.
Artículo
en Chino
| WPRIM
| ID: wpr-748004
ABSTRACT
OBJECTIVE@#To investigate the expressions of LL-37 and IL-8 in chronic sinusitis with nasal polyps.@*METHOD@#Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) and immunohistochemical staining were used to detect the expressions of LL-37 and IL-8 in nasal polyp tissues of 31 patients with chronic sinusitis and inferior turbinate tissues of 11 patients with chronic rhinitis.@*RESULT@#LL-37 and IL-8 mRNA were all positively expressed in all nasal polyps and inferior turbinate tissues. There were significant increases of LL-37 and IL-8 mRNA expressions in nasal polyps compared with the inferior turbinate tissues (P < 0.01). There were also significant increases of positive expression rates of LL-37 and IL-8 protein in nasal polyps, compared with the inferior turbinate tissues (P < 0.01). There was a positive relationship between the mRNA and protein expressions of LL37 and IL-8 (P < 0.01).@*CONCLUSION@#The expressions of LL-37 and IL-8 in nasal polyps suggest that they may play a role in the pathogenesis of chronic sinusitis. Besides its innate immune, LL-37 could enhance human body's anti-infected function by increasing acquired immune.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Sinusitis
/
Pólipos Nasales
/
Enfermedad Crónica
/
Interleucina-8
/
Péptidos Catiónicos Antimicrobianos
/
Catelicidinas
/
Metabolismo
/
Mucosa Nasal
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2010
Tipo del documento:
Artículo
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