Expression and significance of the cyclin E in laryngeal carcinomas / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To investigate the clinicopathological significance of the cyclin E expression in laryngeal squamous cell carcinomas (LSCCs).@*METHOD@#The expression of cyclin E was detected by immunohistochemistry method in 50 cases of LSCCs, 20 cases of dysplastic squamous epithelium and 10 polyps of vocal cord.@*RESULT@#The positive expression of cyclin E was localized in the nuclei of cells. The positive rate of cyclin E protein in LSCCs, dysplastic squamous epithelium and polyps of vocal cord was 10% (1/10), 15% (3/20), 6% (3/50), respectively. There's no significant difference between them. While the expression of cyclin E in laryngeal cancer stromal vascular endothelial cells was significantly related with clinical stage and lymph node metastasis (P<0.01).@*CONCLUSION@#In LSCCs, the expression of cyclin E has non-specificity, probably it has no participate the malignant transform events of laryngeal cancer cells. However, cyclin E is sensitive to vasculogenesis relatively; the positive expression of cyclin E may evaluate the malignant phase of LSCCs indirectly.