The expression and relationship of cyclooxygenase-2 and latent membrane protein-1 in nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 105-108, 2009.
Artículo
en Chino
| WPRIM
| ID: wpr-748271
ABSTRACT
OBJECTIVE@#To discuss the expression and correlation of COX2 and LMP1 in NPC.@*METHOD@#Fifty-three nasopharyngeal biopsy specimens of NPC patients who had been diagnosed definitely with pathology in our department from 2000 to 2005, and 8 nasopharyngeal biopsy specimens of chronic nasopharyngitis patients were collected. The expression of COX2, LMP1 were detected with streptavidin peroxidase immunohistochemistry staining. All the datas were analyzed with SPSS 12.0.@*RESULT@#The positive expression rate of COX2 was 71.70% (38/53), and that of LMP1 was 66.04% (35/53) of Nasopharyngeal carcinoma tissue. The higher expression rate was detected in neck lymph nodes metastasis group of nasopharyngeal carcinoma (P0.05). The expression of COX2 and LMP1 showed positive correlation (gamma = 0.797, P<0.01).@*CONCLUSION@#COX2 and LMP1 were highly expressed in nasopharyngeal carcinoma cells. The expressions of COX2 and LMP1 was significantly associated with neck lymph nodes metastasis, and was none-significant relation with age, gender, clinical stage and pathological classification. The expression of LMP1 showed a significant positive correlation with that of COX2. LMP1 could enhance NPC neck lymph nodes metastasis by up-regulating the expression of COX2.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Carcinoma de Células Escamosas
/
Proteínas de la Matriz Viral
/
Neoplasias Nasofaríngeas
/
Ciclooxigenasa 2
/
Metástasis Linfática
/
Metabolismo
/
Mucosa Nasal
/
Estadificación de Neoplasias
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2009
Tipo del documento:
Artículo
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