Expression of LMP2A, E-Cadherin and fibronectin in nasopharyngeal carcinoma and its clinical significance / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 132-136, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-748763
ABSTRACT
OBJECTIVE@#To investigate the expression of EBV-encoded latent membrane protein 2A (LMP2A) and epithelial-mesenchymal transformation(EMT) associated markers (E-cadherin and fibronectin) in nasopharyngeal carcinoma (NPC) and its clinical significance.@*METHOD@#The expression of LMP2A, E-cad-herin and fibronectin proteins in 32 cases of chronic nasopharyngeal inflammation, 56 cases of NPC and 18 cases of NPC lymph node metastasis were examined byimmunohistochemical SP method.@*RESULT@#(1)The positive rates of LMP2A in NPC and its lymph node metastasis were significantly higher than those of chronic nasopharyngeal inflammation (89. 3%vs 37. 5%o and 77. 8% vs 37. 5%) respectively (both P 0. 05). In addition, LMP2A and E-cadherin expression were significantly correlated with T stage (both P<0. 01).@*CONCLUSION@#LMP2A and fibronectin expressions were increased in NPC, but normal expression of E-cadherin were decreased. LMP2A may promote lymph node metastasis and malignant progression of NPC by induce EMT through downregulation of E-cadherin and upregulation of fibronectin.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Carcinoma
/
Cadherinas
/
Nasofaringe
/
Neoplasias Nasofaríngeas
/
Fibronectinas
/
Transición Epitelial-Mesenquimal
/
Carcinoma Nasofaríngeo
/
Metástasis Linfática
/
Proteínas de la Membrana
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2015
Tipo del documento:
Artículo
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