Expression and clinical significance of cyclooxygenase-2 in nasal and paranasal sinus carcinoma / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#To investigate the relationship between the expression of cyclooxygenase-2 (COX-2) and the carcinogenesis and invasive behavior of nasal and paranasal sinus carcinoma (NPSC).@*METHOD@#The expression of COX-2 were detected in 69 case NPSC tissues, paracancerous atypical hyperplasia tissue and normal tissue by using immunohistochemical techniques of SP method.@*RESULT@#The positive rate of COX-2 in NPSC tissues and atypical hyperplasia tissue and normal tissue was 65.22% and 42.31% and 3.33%, respectively. The positive rate of COX-2 in NPSC tissues was significantly higher than that in normal tissue (P < 0.01), and increased apparently with the lesion progressing from normal to atypical hyperplasia tissue to NPSC tissues, and also correlated with the increasing of tumor (P < 0.05).@*CONCLUSION@#COX-2 may play an important role in the carcinogenesis and invasion of NPSC.