The expression and clinical significance of pepsin and pepsinogen in patients with otitis media with effusion / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 1252-1255, 2015.
Artículo
en Chino
| WPRIM
| ID: wpr-749198
ABSTRACT
OBJECTIVE@#To analyze the role and significance of pepsin and pepsinogen in the pathogenesis of OME in children.@*METHOD@#Pediatric patients with otitis media aged 2-8 years who enrolled in our department of the hospital from May of 2012 to December of 2012 were set as experimental group (38 cases, 48 ears) which should be underwent tympanic membrane puncture/tube insertion. Meanwhile, pediatric patients waiting for cochlear implant without otitis media (10 ears), were set as control group. Middle ear lavage fluid and plasma samples from the two groups were collected and detected using enzyme-linked immune method for pepsin and pepsinogen.@*RESULT@#The concentrations of pepsin and pepsinogen in the middle ear lavage fluid of OME group [(48.8 ± 415.99) ng/ml and 676.32 ± 336.71)ng/ml] were significantly higher than those in the control group [(8.20 ± 4.59)ng/ml and (77.27 ± 50.33) ng/ml] (P 0.05).@*CONCLUSION@#Pepsin and pepsinogen in the middle ear cavity of OME patients maybe originated from laryngopharyngeal reflux (LPR), indicating that LPR is associated with the pathogenesis of OME in children.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cirugía General
/
Membrana Timpánica
/
Otitis Media con Derrame
/
Ensayo de Inmunoadsorción Enzimática
/
Pepsina A
/
Pepsinógeno A
/
Oído Medio
/
Reflujo Laringofaríngeo
/
Metabolismo
Límite:
Niño
/
Child, preschool
/
Humanos
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2015
Tipo del documento:
Artículo
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