Detection and significance of CXCL8 and IL-10 in serum and tissue of the patients' with OSAHS / 临床耳鼻咽喉头颈外科杂志

ABSTRACT

OBJECTIVE@#Detection and significance of CXCL8, IL-10 in serum and tissue of the patients' with OSHAS.@*METHOD@#All subjects take serum CXCL8 and IL-10 levels were determined by ELISA. All subjects take the same position of the soft palate tissues in the operation. CXCL8 and IL-10 in the tissue expression was measured by immune histochemistry.@*RESULT@#(1) Serum CXCL8 levels in OSHAS is higher than that in the control group (P < 0.05). (2) Serum IL-10 levels in OSHAS is lower than that in the control group (P < 0.05). (3) Tissues CXCL8 expression was correlated with serum CXCL8 (r = 0.474, P < 0.05). (4) Tissues IL-10 expression wasn't any correlated with serum IL-10. (5) Tissues IL-10 expression was correlated with tissues CXCL8 (r = 0.482, P < 0.05).@*CONCLUSION@#OSAHS may be a disease associated with inflammation, and closely relate with CXCL8 and IL-10.