Change of auditory brainstem response in hearing deprivation rat model induced by bilateral cochlears ablation / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 465-467, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-749328
ABSTRACT
OBJECTIVE@#To observe the change of auditory brainstem response (ABR) in hearing deprivation rat model induced by bilateral cochlears ablation at different time points.@*METHOD@#Forty SD rats were randomly divided into four experiment groups including 2-week group, 4-week group, 6-week group, 8-week group and four control groups with 5 rats (n = 10) in each group. Then bilateral cochlears ablation was applied to experiment groups. The threshold value of ABR was measured at different time and latent period of each wave was compared.@*RESULT@#The threshold of ABR in experiment group was elevated significantly. The latent period of each wave was pro longed significantly (P < 0.01). In experiment group, the threshold value of ABR in 2-week and 4-week group was significantly greater than that in 6-week group and 8-week group (P < 0.01).@*CONCLUSION@#Bilateral cochlears ablation surgery could elevate the threshold of ABR and latent period of each wave prolonged. The effect of hearing deprivation became apparent after surgery for 4 weeks.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Umbral Auditivo
/
Cirugía General
/
Potenciales Evocados Auditivos del Tronco Encefálico
/
Ratas Sprague-Dawley
/
Cóclea
/
Modelos Animales de Enfermedad
/
Pérdida Auditiva
Límite:
Animales
Idioma:
Chino
Revista:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Año:
2014
Tipo del documento:
Artículo
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