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Expression of p53, p21, PCNA and COX-2 and its relationship with recurrence in the early-stage laryngeal cancer with negative surgical margin / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 349-356, 2016.
Artículo en Chino | WPRIM | ID: wpr-749663
ABSTRACT
OBJECTIVE@#To explore the relation between the expression of p53, p21, PCNA and COX-2 and local recurrence in resection margins of laryngeal carcinoma operation.@*METHOD@#SElect 98 patients with laryngeal carcinoma, who came to our hospital from Nov, 2005 to Dec, 2010. Diagnosed with early laryngeal squamous cell carcinoma by a pathological examination, all these patients received CO2 laser surgery to cut the entire tumors. Keep the primary lesion and resection margin tissues after that and take 5 mm peritumoral tissue as a sample of operation resection margin. With the chemical method of SP, record in detail the local recurrence condition by clinical diagnosis every 3-6 months or telephone follow-up for 2 years.@*RESULT@#(1)The positive rate of p53, p21, PCNA and COX-2 in the tumor tissues of the 98 patients with laryngeal carcinoma are 65. 3%, 52. 0%, 70. 4% and 69. 4%. The positive rate of p53, p21, PCNA and COX-2 in their resection margin tissues are 23. 5%, 39. 8%, 32. 7% and 30. 6%. So there is no relation between the expression of p53, p21, PCNA and COX-2 in tumor tissue and tumorous grading and TNM staging. (2)There appeared 17 cases of local recurrence in two years, with a recurrence rate of 17. 3%. The recurrence rate of patients with a positive expression of p53, p21, PCNA and COX-2 in resection margin tissue is higher than those with a negative expression(P0. 05).@*CONCLUSION@#Through the discussion on the effect of p53, p21, PC- NA and COX-2 in the process of laryngeal carcinoma cell proliferation and local recurrence, the study proposes that biochemical metabolism and molecular structure level abnormal expression occur before the change of cell morphology apparent, and suggests that positive index should be examined regularly and effective foreseeability intervention can be applied to patients with positive expression.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinoma de Células Escamosas / Neoplasias Laríngeas / Proteína p53 Supresora de Tumor / Antígeno Nuclear de Célula en Proliferación / Ciclooxigenasa 2 / Inhibidor p21 de las Quinasas Dependientes de la Ciclina / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello / Metabolismo / Recurrencia Local de Neoplasia Límite: Humanos Idioma: Chino Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Año: 2016 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Carcinoma de Células Escamosas / Neoplasias Laríngeas / Proteína p53 Supresora de Tumor / Antígeno Nuclear de Célula en Proliferación / Ciclooxigenasa 2 / Inhibidor p21 de las Quinasas Dependientes de la Ciclina / Carcinoma de Células Escamosas de Cabeza y Cuello / Neoplasias de Cabeza y Cuello / Metabolismo / Recurrencia Local de Neoplasia Límite: Humanos Idioma: Chino Revista: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Año: 2016 Tipo del documento: Artículo