Recent progress of elucidating the mechanisms of drug hypersensitivity
Asia Pacific Allergy
;
(4): 203-209, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-749907
ABSTRACT
Recent technical approaches to investigating drug hypersensitivity have provided a great deal of information to solve the mechanisms that remain poorly understood. First, immunological investigations and in silico analysis have revealed that a novel interaction between T cells and antigen-presenting cells, namely the pharmacological interaction concept, is involved in drug recognition and the hapten theory. Second, progress in immunology has provided a new concept of CD4+ T cell subsets. Th17 cells have proven to be a critical player in acute generalized exanthematous pustulosis. Our recent findings suggest that this subset might contribute to the pathogenesis of Stevens-Johnson syndrome/toxic epidermal necrolysis. Third, alarmins, molecules associated with innate immunity, are also associated with exaggeration and the persistence of severe drug hypersensitivity. The latest innovative techniques are providing a new landscape to examine drug hypersensitivity.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Simulación por Computador
/
Receptores de Antígenos de Linfocitos T
/
Linfocitos T
/
Subgrupos de Linfocitos T
/
Hipersensibilidad a las Drogas
/
Alergia e Inmunología
/
Pustulosis Exantematosa Generalizada Aguda
/
Células Th17
/
Alarminas
/
Hipersensibilidad
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Asia Pacific Allergy
Año:
2012
Tipo del documento:
Artículo
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