Oral antiplatelet agent hypersensitivity and cross-reactivity managed by successful desensitisation
Asia Pacific Allergy
;
(4): 51-54, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-750009
ABSTRACT
Oral platelet aggregation inhibitors are widely used for the treatment and prevention of cardiovascular diseases, including coronary stent thrombosis. Premature discontinuation following percutaneous coronary intervention would pose a grave risk of in-stent thrombosis, acute myocardial infarction and eventual death. Although they share the same mechanism of adenosine diphosphate P2Y12 platelet receptor inhibition, they belong to either the chemical class of thienopyridines (clopidogrel, prasugrel, and ticlopidine) or cyclopentyl-triazolo-pyrimidines (ticagrelor and cangrelor). This case describes the first documented cross-reactive hypersensitivity of clopidogrel towards both its fellow thienopyridine, prasugrel, as well as the structurally dissimilar ticagrelor, and its subsequent successful desensitisation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Trombosis
/
Plaquetas
/
Inhibidores de Agregación Plaquetaria
/
Enfermedades Cardiovasculares
/
Stents
/
Adenosina Difosfato
/
Desensibilización Inmunológica
/
Reacciones Cruzadas
/
Tienopiridinas
/
Intervención Coronaria Percutánea
Idioma:
Inglés
Revista:
Asia Pacific Allergy
Año:
2015
Tipo del documento:
Artículo
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