Economic value of atopic dermatitis prevention via infant formula use in high-risk Malaysian infants
Asia Pacific Allergy
;
(4): 84-97, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-750022
ABSTRACT
BACKGROUND:
Breastfeeding is best for infants and the World Health Organization recommends exclusive breastfeeding for at least the first 6 months of life. For those who are unable to be breastfed, previous studies demonstrate that feeding high-risk infants with hydrolyzed formulas instead of cow's milk formula (CMF) may decrease the risk of atopic dermatitis (AD).OBJECTIVE:
To estimate the economic impact of feeding high-risk, not exclusively breastfed, urban Malaysian infants with partiallyhydrolyzed whey-based formula (PHF-W) instead of CMF for the first 17 weeks of life as an AD risk reduction strategy.METHODS:
A cohort Markov model simulated the AD incidence and burden from birth to age 6 years in the target population fed with PHF-W vs. CMF. The model integrated published clinical and epidemiologic data, local cost data, and expert opinion. Modeled outcomes included AD-risk reduction, time spent post AD diagnosis, days without AD flare, quality-adjusted life years (QALYs), and costs (direct and indirect). Outcomes were discounted at 3% per year. Costs are expressed in Malaysian Ringgit (MYR; MYR 1,000 = United States dollar [US $]316.50).RESULTS:
Feeding a high-risk infant PHF-W vs. CMF resulted in a 14% point reduction in AD risk (95% confidence interval [CI], 3%-23%), a 0.69-year (95% CI, 0.25-1.10) reduction in time spent post-AD diagnosis, additional 38 (95% CI, 2-94) days without AD flare, and an undiscounted gain of 0.041 (95% CI, 0.007-0.103) QALYs. The discounted AD-related 6-year cost estimates when feeding a high-risk infant with PHF-W were MYR 1,758 (US $556) (95% CI, MYR 917-3,033) and with CMF MYR 2,871 (US $909) (95% CI, MYR 1,697-4,278), resulting in a per-child net saving of MYR 1,113 (US $352) (95% CI, MYR 317-1,884) favoring PHF-W.CONCLUSION:
Using PHF-W instead of CMF in this population is expected to result in AD-related costs savings.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estados Unidos
/
Organización Mundial de la Salud
/
Lactancia Materna
/
Incidencia
/
Estudios de Cohortes
/
Análisis Costo-Beneficio
/
Años de Vida Ajustados por Calidad de Vida
/
Conducta de Reducción del Riesgo
/
Parto
/
Fórmulas Infantiles
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Evaluación Económica en Salud
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
/
Lactante
País/Región como asunto:
America del Norte
Idioma:
Inglés
Revista:
Asia Pacific Allergy
Año:
2015
Tipo del documento:
Artículo
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