Intravenous tacrolimus and cyclosporine induced anaphylaxis: what is next?
Asia Pacific Allergy
;
(4): 181-186, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-750028
ABSTRACT
Tacrolimus and cyclosporine have been used in various formulations, but their hypersensitivity reactions are rare in practice. Castor oil derivatives are nonionic surfactants used in aqueous preparations of hydrophobic active pharmaceutical ingredients. Castor oil derivatives that can be used as additives to tacrolimus and cyclosporine may play a role in the development of hypersensitivity reactions, especially anaphylaxis. Various immunologic and nonimmunologic mechanisms have been implicated in hypersensitivity reactions induced by castor oil derivatives. Physicians should be aware that not only the drug itself, but also its additives or metabolites could induce hypersensitivity reactions. We report a case of anaphylaxis caused by vitamin K (phytonadine), serotonin antagonist (granisetron), intravenous tacrolimus, and cyclosporine. Interestingly, the patient tolerated oral cyclosporine, which did not contain Cremophor EL or polysorbate 80.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Polisorbatos
/
Tensoactivos
/
Vitamina K
/
Aceite de Ricino
/
Serotonina
/
Tacrolimus
/
Ciclosporina
/
Hipersensibilidad
/
Anafilaxia
Límite:
Humanos
Idioma:
Inglés
Revista:
Asia Pacific Allergy
Año:
2015
Tipo del documento:
Artículo
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