Severe anti-D haemolytic disease of fetal and newborn in rhesus D negative primigravida
The Malaysian Journal of Pathology
; : 55-58, 2019.
Article
en En
| WPRIM
| ID: wpr-750406
Biblioteca responsable:
WPRO
ABSTRACT
@#Introduction: Anti-D alloimmunisation may occur from the blood transfusion or fetomaternal haemorrhage which can lead to haemolytic disease of fetal and newborn (HDFN). The morbidity and mortality of HDFN related to anti-D is significantly reduced after introduction of anti-D prophylaxis and furthermore, anti-D HDFN in RhD negative primigravida is uncommonly seen. Case Report: A case of unusual severe HDFN due to anti-D alloimmunisation in undiagnosed RhD negative primigravida Malay woman is reported here. This case illustrates the possibility of an anamnestic response from previous unknown sensitisation event or the development of anti-D in mid trimester. The newborn expired due to hydrops fetalis and severe anaemia. Antenatally, the mother was identified as RhD positive and thus there was no antenatal antibody screening, antepartum anti-D prophylaxis or close fetal monitoring for HDFN. Discussion: The thorough antenatal ABO and RhD blood grouping with antibody screening is mandatory as part of prevention and early detection of HDFN especially due to anti-D alloimmunisation. Improper management of RhD negative women might lead to severe HDFN including in primigravida.
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WPRIM
Tipo de estudio:
Prognostic_studies
/
Screening_studies
Idioma:
En
Revista:
The Malaysian Journal of Pathology
Año:
2019
Tipo del documento:
Article