Endocannabinoid receptor type 2 in central nervous system disorders / 国际儿科学杂志

ABSTRACT

The endocannabinoid system is composed of endocannabinoids,enzymes for the biosynthesis and degradation of endocannabinoids,and specific cannabinoid receptors (cannabinoid receptor type 1,CB1R;cannabinoid receptor type 2,CB2R).The previous view is that CB1Rs are mainly expressed in the central neurons,whereas CB2Rs are predominantly expressed in peripheral immune cells.However,there is emerging strong evidence that CB2Rs are moderately expressed and function in specific brain areas.CB2Rs in the central nervous system (CNS) takes part in occurrence and progression of Alzheimer's disease,traumatic brain injury,intracranial hemorrhage and epilepsy.This review summarizes the CB2Rs and the effect in central nervous system disorders.