Research progress on the relationship between sepsis and intestinal barrier function / 国际儿科学杂志

ABSTRACT

Sepsis is attracting more attention recently, which endangering health of children. The gut, as the largest repository of bacteria, has long been hypothesized to be the motor of multiple organ dysfunc-tion syndrome. The changes are tightly associated with intestinal barrier function, epithelial cells and intestinal permeability. The intestinal commensal microflora is also altered in sepsis, with increases in microbial viru-lence and decreases in diversity, which leads to further pathologic responses within the host. This review focu-ses on the pathogenesis and the relation between sepsis and intestinal barrier function.