Factors influencing paediatric antithrombin Ⅲ detection / 国际儿科学杂志

ABSTRACT

Antithrombin Ⅲ (AT-Ⅲ) is a single chain glycoprotein secreted by liver and vascular endothelial cells with a half-life of 2.69 days and is one of the important members of the broad-spectrum serine protein inhibitor family.AT-Ⅲ plays an important role in anticoagulant regulation in the human body,accounting for about 70％-80％ of the total activity of the plasma anticoagulant system.It is involved in maintaining the homeostasis of the coagulation system and anticoagulant system in the body.In recent years,pediatricians have found that the AT-Ⅲ index has important clinical value in evaluating children's thrombosis,sepsis and nephrotic syndrome.This article mainly reviews the factors influencing the detection of antithrombin Ⅲ in children.