Platelet-associated microRNA and platelet reactivity in patients with ischemic stroke / 国际脑血管病杂志

ABSTRACT

Platelets contain a large number of microRNAs (miRNAs),for example,miR-223,miR-126,and miR-191 are highly expressed in platelets,affecting platelet reactivity through different targets.Platelet-associated miRNAs are involved in platelet activation and are associated with the onset risk and outcome of ischemic stroke,and may be a novel marker for early diagnosis and prognostic evaluation of ischemic stroke and provide new therapeutic targets for ischemic stroke.Moreover,platelet-associated miRNAs may play a regulatory role in platelet function and gene expression,and have potential role in evaluating the efficacy of antiplatelet drugs,especially in screening high on-treatment platelet reactivity and high-risk patients as early as possible to guide individualized treatment of antiplatelet drugs.