Correlation between anemia and stroke severity and short-term outcome in elderly patients with acute ischemic stroke / 国际脑血管病杂志

ABSTRACT

Objective To investigate the correlation between anemia and stroke severity and short-term outcome in elderly patients with acute ischemic stroke. Methods Elderly patients with acute ischemic stroke (age≥60 years) admitted to the Department of Neurology, the Second Hospital of Tianjin Medical University between January 2015 and December 2017 were enrolled retrospectively. The demographic and clinical data were collected. The National Institutes of Health Stroke Scale (NIHSS) score at admission was used to evaluate the neurologic deficits, ≤8 was defined as a mild stroke and >8 was defined as moderate to severe stroke. Clinical outcomes were assessed using the modified Rankin Scale (mRS) at discharge or 14 d after onset (whichever occurs first), with 0 to 2 defined as a good outcome and >2 as a poor outcome. Multivariate logistic regression analysis was used to determine the independent influencing factors of the severity and early outcome of stroke. Results A total of 516 patients were enrolled in the study, their age was 74.10 ± 8.64 years, and 291 (56.4% ) were males; 111 (21.5% ) in anemia group and 405 (78.5% ) in non-anemia group, 336 (65.1% ) in mild stroke group, 180 (34.9% ) in moderate to severe stroke group, 303 (58.7% ) in good outcome group, and 213 (41.3% ) in poor outcome group. Univariate analysis showed that the proportion of patients with anemia in the moderate to severe stroke group was significantly higher than that in the mild stroke group (29.4% vs. 17.3% ; χ2 =10.303, P=0.001). The proportion of patients with anemia in the poor outcome group was significantly higher than that in the good outcome group (32.9% vs. 13.5% ; χ2 = 27.687, P< 0.001 ). Multivariate logistic regression analysis showed that anemia was an independent risk factor for stroke severity (odds ratio 3.263, 95% confidence interval 1.446-7.361; P=0.004) and short-term poor outcome (odds ratio 1.928, 95% confidence interval 1.609-2.311; P= 0.029 ). Conclusions Anemia is significantly associated with stroke severity and short-term outcome in elderly patients with acute ischemic stroke.