Regulating effect of lncRNA on aerobic glycolysis in tumor cells / 国际肿瘤学杂志

ABSTRACT

Long noncoding RNA (lncRNA) is a kind of RNA with a length greater than 200 nucleotides and lacks protein-coding function.Varieties of lncRNAs have been found to play major roles in the aerobic glycolysis of tumor cells,such as lncRNA-p21,H19,prostate specific transcript 1 (PGCEM1) and so on.In tumor cells,lncRNA can directly regulate the rate-limiting enzyme in the glycolytic pathway,also can indirectly regulate the glycolysis by hypoxia inducible factor-1α (HIF-1α) or proto-oncogene c-myc.Further study on the mechanism of lncRNA regulating tumor cell glycolysis is expected to open up new ideas for the diagnosis and treatment of tumor diseases.