Clinical effect of Guben-Huoxue decoction on chronic obstructive pulmonary disease / 国际中医中药杂志

ABSTRACT

Objective To explore the clinical effect of Guben-Huoxue decoction on chronic obstructive pulmonary disease (COPD) and its influence on patients'respiratory rehabilitation and quality of life. Methods A total 108 patients with COPD admitted to our hospital from May 2013 to January 2018 were selected as the research subjects. The patients were divided into control group and observation group by random number table grouping method, 54 in each group. All patients were given basic treatment such as oxygen inhalation, anti-infection, bronchiectasis, and correction of acidosis. The control group was treated with budesonide formoterol powder inhalation, while the observation group was treated with Guben-Huoxue decoction on the basis of the control group. The maximum ventilation volume per minute (MVV), forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), forced expiratory volume in the second (FEV1%) were measured by pulmonary function meter. Adverse reactions were recorded. Results The difference of FVC, MVV, FEV1%, symptoms, activity ability, disease influence and comprehensive scores in the observation group were significantly greater than those in the control group (t values were 6.480, 13.679, 5.853, 3.743, 5.786, 5.309, 5.058, respectively, all Ps<0.05). The total effective rate (94.4%) in the observation group were significantly higher than those in the control group (79.6%); the total incidence of adverse reactions (9.3%) was significantly lower than that of the control group (25.9%), and the difference was statistically significant (P<0.05). Conclusions The Guben-Huoxue decoction can improve the clinical symptoms and pulmonary function of COPD patients, promote respiratory rehabilitation and improve the quality of life.