An Analysis of Biochemical Characteristics of Liver Injury In Duced by Statins / 昆明医科大学学报

ABSTRACT

Objectives To provide theoretical basis for the clinical rational using of drugs, biochemical characteristics of the liver injuries induced by the atorvastatin, simvastatin and lovastatin were analyzed and compared by replicating the rats model of liver injuries induced by statins, Methods 80 SPF SD rats (8 weeks of age), half male and half female, were divided into four groups randomly control group, simvastatin group, lovastatin group, atorvastatin group. Human equivalent doses were administered to the latter three groups of rats which were sacrificed to draw blood on the 10 th, 35 th and 55 th day respectively (via the femoral artery) for testing liver function index, including total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), aspartateaminotransferase (AST), alanineaminotransferase (ALT), alkalinephosphatase (ALP). Results (1) The increases in TBIL, DBIL, IBIL for treatment group in comparison with control group had statistical significance (P＜0.01).2) At the 55 th day of administration, there was a significant statistical difference between the simvastatin group and the lovastatin group in AST (P＜0.05);3) Meanwhile, there was great statistical difference between the atorvastatin group and lovastatin group in ALP (P＜0.01). Conclusion The rats in the three experimental groups suffered from minor to moderate liver injuries, most of which being cholestasis type. It is speculated that this kind of liver injuries are closely related to the obstacle of transfering bile.