Toll-like receptor signaling pathway as a potential therapeutic target for colorectal cancer / 实用肿瘤学杂志

ABSTRACT

Toll-like receptors(TLRs) signaling pathways are involved in the activation of innate and adaptive immune re-sponse and play an important role in the development of colorectal cancer. Deregulation of TLRs signaling pathway can lead to epitheli-al hemorrhage,chronic inflammation and the development of colorectal cancer. There is now lots of evidence that targeting this pathway will benefit the treatment of colorectal cancer,such as BCG,monophosphatidyl A,and iquimod,etc. ,which are now in clinical use. This article reviews current different function of TLRs in tumor development and their application in the treatment of colorectal cancer.