Effects of full-course epidural delivery on puerpera and neonatal / 中国基层医药

ABSTRACT

Objective To investigate the effects of epidural analgesia on puerpera and neonatal.Methods A total of 150 puerpera were continuously enrolled from May 2017 to May 2018 in Zhoushan Maternal and Child Health Care Hospital,and were divided into analgesia group (102 cases) and non-analgesia group (48 cases) according to their prenatal wishes.The analgesia group was given epidural anesthesia for analgesic delivery,while the control group had no analgesia intervention.Differences in the expression of serum pain and stress hormones were compared between two groups at the time of prenatal,postpartum 1h and 24h.At the same time,differences in neonatal NACS scores were compared between two groups at the time of postpartum 1h,8h and 24h.Results No statistically significant differ-ences were found between the two groups in prenatal serum pain and stress hormones,but at the time of postpartum 1h and 24h,serum pain media neuropeptide Y ( NPY) ( t = 5. 041, P = 0. 000; t = 4. 984, P = 0. 000 ), 5 -hydroxytryptamine (5-HT) (t=3.083,P=0.002;t=4.203,P=0.000),prostate E2 ( PGE2) ( t=6.764,P=0.000;t=4.364,P=0.000) and stress hormone angiotensin Ⅱ(AngⅡ) (t=3.670,P=0.000;t=2.911,P=0.004),adrenocorticotropic hormone (ACTH)[(212.54 ± 38.65) ng/mL vs.(231.43 ± 34.82)ng/mL,t=3.510, P=0.001; (163.82 ± 33.21) ng/mL vs.(175.21 ± 32.48) ng/mL,t=2.105,P=0.045)] and cortisol (Cor) [(344.56 ± 57.39) μg/L vs.(381.81 ± 59.23)μg/L,t=3.670,P=0.000; (241.27 ± 43.44) μg/L vs.(262.56 ± 37.97) μg/L,t=2.911,P=0.004)] in the analgesia group were significantly lower than those in the non-analge-sia group.There were no statistically significant differences in NACS score,complications and Apgar score between the two groups (all P>0.05).Conclusion The analgesic effect of full-course epidural delivery in analgesic delivery is remarkable,which can effectively reduce maternal stress reaction, and it is safe and has less adverse effect on neonates.