Effect of statins on prognosis of senile diabetes mellitus complicated with cerebral infarction / 中国基层医药

ABSTRACT

Objective To investigate the effect of statins on the prognosis of senile diabetic patients with cerebral infarction.Methods Sixty-two elderly patients with diabetes mellitus and cerebral infarction admitted to Shantou Central Hospital from June 2016 to June 2017 were selected.Thirty patients who took atorvastatin(10 mg/d) six months before onset were selected as observation group.At the same time,32 cases of cerebral infarction who were not given statins were selected as control group.The risk factors on admission to hospital,fasting glucose,glycosylated hemoglobin,blood lipid levels and neural function defect were compared between the two groups.The nerve function defect was evaluated after treatment for 2 weeks.Results In the observation group,the rates of drinking,smoking,coronary heart disease,hyperlipidemia,previous stroke and hypertension were 20.00％,63.34％,50.00％,73.33％,40.00％,70.00％,respectively,compared with the control group (28.00％,65.63％,56.25％,71.88％,34.38％,75.00％),there were no statistically significant differences (x2 =0.121,0.213,0.197,0.195,0.142,0.139,P =0.327,0.644,0.542,0.530,0.475,0.453).The triglyceride,total cholesterol,low density lipoprotein cholesterol and high density lipoprotein cholesterol in the observation group were (3.68 ±0.81) mmol/L,(1.35 ±0.46) mmol/L,(2.65 ± 1.36) mmol/L,(1.38 ± 0.56) mmol/L,respectively,which in the control group were (5.45 ± 1.24) mmol/L,(1.83 ± 0.76) mmol/L,(3.89 ± 1.51) mmol/L,(0.92 ± 0.33) mmol/L,respectively,the differences were statistically significant between the two groups (t =5.621,5.825,4.916,5.103,P =0.012,0.013,0.022,0.020).The levels of blood glucose and glycosylated hemoglobin in the observation group were (6.58 ± 2.87)mmol/L,(7.18 ±1.48)％,respectively,which in the control group were (6.84 ± 3.14) mmol/L,(7.05 ± 1.49) ％,respectively,the differences were statistically significant (t =1.049,1.199,P =0.301,0.362).The national institutes of health stroke scale (NIHSS) scores of the control group before and after treatment were (15.2 ± 4.3) points and (4.9 ± 0.8) points,respectively,which were higher than those of the observation group [(14.8 ± 3.8)points and (7.1 ± 0.7)points],and the differences were statistically significant (t =4.879,5.268,P =0.028,0.016).Conclusion The primary prevention of statins can improve the blood lipid level and nerve function of senile diabetic patients with cerebral infarction,as well as reduce the degree of disability.