Surveillance report of antimicrobial resistance in the clinical isolates from the First Affiliated Hospital of Anhui Medical University during 2016 / 中国感染与化疗杂志

ABSTRACT

Objective To report the distribution and antibiotic resistance of bacterial strains isolated in the First Affiliated Hospital of Anhui Medical University during 2016 for improving clinical treatment of bacterial infections. Methods Antimicrobial susceptibility testing was carried out according to a unified protocol using Kirby-Bauer method or automated systems. The results were interpreted according to the clinical and laboratory standards institute (CLSI) 2015 breakpoints, and analyzed using WHONWT 5.6. Results A total of 5 406 clinical isolates were collected during 2016, of which gram positive organisms accounted for 25.6％ (1 386/5 406) and gram negative organisms 74.4％ (4 020/5 406). The strains were mainly isolated from respiratory tract (35.4％, 1 913/5 406) and urine (26.7％, 1 441/5 406). The most frequently isolated microorganisms were E. coli (23.1％, 1 247/5 406), followed by K. pneumoniae (12.1％,654/5 406). The prevalence of MRSA was 52.2％ (166/318). The prevalence of MRCNS was 80.3％ (462/575). Of the ESBLs producers, E. coli accounted for 59.7％ (745/1 247), and K. pneumoniae accounted for 30.6％(200/654). ESBLs-producing strains showed significantly higher resistance rates to most antibiotics than non-ESBLs-producing strains. All the E. faecalis strains were susceptible to vancomycin. A few (0.2％) of the E. faecium strains were resistant to vancomycin, which were all from urine specimens. A total of 1 046 (19.3％, 1 046/5 406) carbapenemresistant strains were isolated. Most Enterobacteriaceae isolates were still highly sensitive to carbapenems. Carbapenem-resistant isolates were mainly A. baumannii (41.1％, 430/1 046), P. aeruginosa (17.4％, 182/1 046)) and K. pneumoniae (12.0％, 126/1 046). Most Acinetobacter strains were resistant to most of the antibiotics tested. Conclusions Antimicrobial resistance is increasing in the clinical isolates in this hospital. We should continue to strengthen antimicrobial stewardship, prescribe antibiotics for strict indications, and improve rational antibiotic use.