Surveillance of antimicrobial resistance in the First Affiliated Hospital of Bengbu Medical College in 2017 / 中国感染与化疗杂志

ABSTRACT

Objective To investigate the distribution and antibiotic resistance profile of clinical isolates in the First Affiliated Hospital of Bengbu Medical College in 2017. Methods Antimicrobial susceptibility testing was carried out by automated systems or Kirby-Bauer method. The data were interpreted according to CLSI 2017 breakpoints and analyzed by WHONET 5.6 software. Results A total of 4 295 strains of bacteria were isolated in 2017, including 1 196 (27.8％) strains of gram-positive bacteria, and 3 099 (72.2％) strains of gram-negative organisms. Methicillin-resistant Staphyloccus aureus and methicillin-resistant coagulasenegative Staphylococcus isolates accounted for 54.7％ and 77.4％, respectively. The resistance rates of methicillin-resistant strains to most of antibiotics tested (except trimethoprim-sulfamethoxazole) were significantly higher than those of methicillinsusceptible strains. None strains were found resistant to linezolid or vancomycin. E. faecium and E. faecalis were the major isolatesin Enterococcus. The resistance rates of E. faecalis to most antibiotics (except tetracyclines and linezolid) were much lower than those of E. faecium. A few Enterococcus strains were resistant to linezolid and vancomycin. A few strains of penicillin-resistant Streptococcus pneumoniae were identified. ESBLs-producing strains accounted for 66.0％ in E. coli and 22.7％ in K. pneumoniae. The resistance rate of Enterobacteriaceae to carbapenems was increasing. Theresistance rates of Klebsiella pneumoniae, Enterobacteriaceae and Citrobacter to imipenem and ertapenem were higher than 10％. The resistance rates of P. aeruginosa to imipenem was 43.3％, but lower than 30％ to ceftazidime, cefepime, piperacillin-tazobactam, and levofloxacin. The resistance rates of A. baumannii to all the antibiotics tested except amikacin were higher than 70％, and the resistance rate to imipenem was 87.5％. The prevalence of extensively drug-resistant strains in P. aeruginosa, K. pneumoniae and A. baumannii was 15.8％, 28.4％, and 46.7％, respectively. Conclusions Antimicrobial resistance was serious in this hospital in 2017. Especially, carbapenem-resistant Enterobacteriaceae and extensively drug-resistant K. pneumoniae were increasing. Therefore, more attention should be paid to rational use of antibiotics and antibiotic resistance surveillance.