Relationship between early onset diabetes mellitus and atherosclerosis in patients with type 2 diabetic kidney disease / 中国医师杂志

ABSTRACT

Objective To investigate the relationship between early onset diabetes mellitus and atherosclerosis in patients with type 2 diabetic kidney disease.Methods Total 240 hospitalized patients (91 females and 149 males) in our hospital with type 2 diabetic kidney disease from January 2017 to December 2017 were enrolled.According to the age of newly diagnosed diabetes mellitus,the patients were divided into early onset group (the age at first diagnosis of diabetes was ＜ 40 years old,n =46) and late onset group (the age at first diagnosis of diabetes was ≥ 40 years old,n =194).The clinical data,anthropological measurements were collected.The relationships between early onset diabetes mellitus and atherosclerosis were analyzed by t test,u test,and Chi square test for statistical analysis.Logistic regression analysis was performed to obtain odds ratios (OR) for early versus late onset of T2DM.Results Compared with the late onset group,the early onset group was younger,less complicated with hypertension,shorter duration of hypertension,less use of renin-angiotensin-aldosterone system (RAAS) inhibitors and other types of antihypertensive drugs and lipid-lowering drugs (P ＜ 0.05).However,the prevalence of atherosclerosis in early onset group was increased (76.1％ vs 59.3％,P=0.034).There were no significant difference in disease duration,smoking,body mass index (BMI),systolic blood pressure (SBP),diastolic blood pressure (DBP),low density lipoprotein (LDL-C) and glycosylated hemoglobin (HbA1 c) between the two groups.Univariate logistics regression analysis showed early onset type 2 diabetes mellitus,age and duration of diabetes were predictors of atherosclerosis (P ＜ 0.05).With the use of multivariate logistic regression,patients with early onset diabetes had higher risks for atherosclerosis when adjusted by gender,age,metabolic factors and disease duration (OR 2.93,95％ CI1.24,6.93,P =0.014).Conclusions Early onset diabetes mellitus increases the risk of atherosclerosis in patients with type 2 diabetic kidney disease.