DTI study of neonatal hyperbilirubinemia brain injury based on cerebellar dentate nucleus / 中国医师杂志

ABSTRACT

Objective Magnetic resonance diffusion tensor imaging ( DTI) technique was used to investigate the changes of DTI parameters in nerve fiber bundles of children with hyperbilirubinemia. Meth-ods A retrospective analysis of DTI imaging data of 43 children with hyperbilirubinemia and 24 normal controls in our hospital using the German Siemens 3. 0t Trio superconducting magnetic resonance imaging in-strument from December 2016 to March 2018. Children with hyperbilirubinemia were divided into two groups, total serum bilirubin mildly elevated group (34 cases) and total serum bilirubin moderate to severe elevation group (9 cases). The right and left cerebellar dentate nuclei were selected as the regions of inter-est. Relevant parameters were measured, and the parameters of each group were analyzed and compared. Results Compared with the normal control group,the fractional anisotropy ( FA) of the total serum biliru-bin mildly elevated group was decreased ( P=0. 022 ) and the volume ratio ( VR ) of that was increased (P=0. 036). Compared with the normal control group, the FA of the total serum bilirubin moderate to se-vere elevation group was decreased (P=0. 002) and the VR of that was increased (P=0. 047). Compared with the total serum bilirubin mildly elevated group,the FA of the total serum bilirubin moderate to severe elevation group was decreased (P=0. 035). In addition, in the cerebellar dentate nucleus, there was a lin-ear negative correlation (r= -0. 201, P=0. 029) between the FA values and the total bilirubin level, while linear positive correlation (r=0. 245, P=0. 045) between the VR value and the total bilirubin level. Conclusions There are changes in FA and VR values of the cerebellar dentate nucleus in children with hy-perbilirubinemia,which of them are linearly related to bilirubin levels. It can early indicate the destruction or dysplasia of nerve fiber bundles in children.