Effects of Bufei Yishen Huoxue Prescription Combined with Western Routine Treatment on Bone Metabolism in Patients with Chronic Obstructive Pulmonary Disease / 中国中医药信息杂志

ABSTRACT

Objective To observe the effects of Bufei Yishen Huoxue Prescription combined with Western routine treatment on bone metabolism in patients with chronic obstructive pulmonary disease (COPD). Methods Totally 60 patients with COPD (GOLD level 2/3, comprehensive evaluation B/C group) were randomly divided into observation group and control group through randomized and parallel method, with 30 cases in each group. Patients of the control group were treated with COPD Western routine treatment. Patients of the observation group were treated with Bufei Yishen Huoxue Prescription on the basis of the control group, one dosage per day, twice a day, orally. The treatment for both groups lasted for 12 weeks. TCM symptom scores, levels of P1 NP and β-CTX, and bone mineral density in both groups were observed before and after treatment. Results Compared with before treatment, the total score of TCM symptom scores, scores of wheezing, expectoration, chest tightness, weakness of waist and knees, and frequent night urination in the observation group decreased significantly, with statistical significance (P＜0.05). After treatment, the total score of TCM symptom scores in the observation group was significantly lower than that in the control group (P＜0.05). After treatment, the decline degree of total score of TCM symptom scores, scores of wheezing, chest tightness, fatigue, weakness of waist and knees in the observation group were better than the control group, with statistical significance (P＜0.05). After treatment, the increase of P1 NP in the observation group was significantly higher than that in the control group (P＜0.05). β-CTX showed a downward trend after treatment, without statistical significance (P＞0.05). After treatment, there was 1 case of dry mouth in each group and 1 case of loss of appetite in the observation group. There was no obvious adverse reaction. Conclusion Bufei Yishen Huoxue Prescription combined with Western routine treatment can effectively relieve the clinical symptoms of patients with COPD, restore the functional state of osteoblast, and improve bone metabolism.