The Mechanism of Tissue Injury in the Animal Model of Experimental Retinal Vein Occlusion
Journal of the Korean Ophthalmological Society
; : 154-160, 1999.
Article
en Ko
| WPRIM
| ID: wpr-75479
Biblioteca responsable:
WPRO
ABSTRACT
We investigated the development of programmed cell death of apoptosis as a mechanism of cell death in experimental retinal vein occlusion of rats. We induced hemicentral retinal veinocclusion by photocoagulation 3 or 4 out of 6 retinal veins after infecting rose bengal intravenously.The eyes were enucleated sequentially between day one to day fourteen, and the retinas were examined after H&E and TUNEL staining. Exudative retinal detachment developed one day after vein occlusion and was reabsorbed completely by day 4. The number of ganglion cells in vein-occluded retina began to decrease one day after vein occlusion and continue to decrease until day fourteen. Many cells in ganglion cell layer and inner nuclear layer were stained positively by TUNEL staining. These results suggest that apoptosis is an important mechanism of cell death in early stage of experimental retinal vein occlusion.
Palabras clave
Texto completo:
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Índice:
WPRIM
Asunto principal:
Retina
/
Vena Retiniana
/
Retinaldehído
/
Rosa Bengala
/
Venas
/
Oclusión de la Vena Retiniana
/
Desprendimiento de Retina
/
Muerte Celular
/
Apoptosis
/
Etiquetado Corte-Fin in Situ
Límite:
Animals
Idioma:
Ko
Revista:
Journal of the Korean Ophthalmological Society
Año:
1999
Tipo del documento:
Article