Clinical and research progress of congenital adrenal hyperplasia with adrenal rest tumor / 中华内分泌代谢杂志

ABSTRACT

Adrenal rest tumor ( ART ) is a well-known complication in congenital adrenal hyperplasia (CAH),which may occur in all age groups, especially in adolescence and adulthood. Tumors that occur in the testicular known as testicularadrenal rest tumor ( TART ) , in the ovarian and parovarian tissue known as ovarian adrenal rest tumor ( OART) . ART is one of the major causes of reproductive dysfunction in adult with CAH. Early prevention and treatment is the key to avoid irreversible damage to gonadal function. In the past, we paid more attention to TART in children, while ignored TART and OART in adults. This article will review the origin of tumor cells, pathogenesis, epidemiology, diagnosis, treatment and prognosis of CAH associated with ART, which aims to guide clinical work through the profound understanding of CAH with ART.