Determination of serum troponin levels in patients with acute ischemic stroke / 中华全科医师杂志

ABSTRACT

From October 2017 to March 2018,398 patients with acute ischemic stroke admitted in Department of Neurology,First Hospital of Shanxi Medical University were enrolled in the study,including 59 cases with elevated troponin (cTn) and 339 cases with normal cTn level.Patients were assessed with National institute of Health Stroke Scale (NIHSS),Chinese Ischemic Stroke Subclassification (CISS),Island cortical lesions and related non-neurological diseases.The short-term prognosis was assessed by NIHSS score during 10-15 days in hospital and compared between the two groups.Multivariate regression analysis showed that elevated serum cTn was independently associated with insular cortex damage (OR=2.87,95％CI1.26-6.53),NIHSS score at admission (OR=1.08,95％ CI1.01-1.14),hemorrhagic transformation (OR=6.71,95％ CI2.21-20.38),cancer (OR=5.04,95％ CI1.43-17.77),and the level of serum creatinine (OR=1.02,95％CI1.01-1.03).Increased serum cTn in acute ischemic stroke is associated with severe neurological deficits,insular cortex damage and non-neurological diseases.Aacute ischemic stroke patients with increased serum troponin have a more severe prognosis.