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Helicobacter pylori: A Possible Risk Factor for Bone Health / 가정의학회지
Korean Journal of Family Medicine ; : 239-244, 2015.
Artículo en Inglés | WPRIM | ID: wpr-7563
ABSTRACT

BACKGROUND:

Helicobacter pylori (H. pylori) infection may cause systemic inflammation and increase the production of tumor necrosis factor-alpha, interleukin-1, and interleukin-6. Unfortunately, bone mineral density also may be affected by these cytokines. This study aimed to evaluate the association between bone mineral density and H. pylori infection.

METHODS:

A cross-sectional study evaluated 1,126 men undergoing a comprehensive health screening in a private Korean screening center. Subjects' sera were tested for H. pylori antibodies (immunoglobulin G) using an enzyme-linked immunosorbent assay, and bone mineral densities (g/cm2) of the lumbar spine, femoral neck, and total femur were obtained using dual-energy X-ray absorptiometry. To evaluate the difference in bone mineral density according to H. pylori infection status, the adjusted mean bone mineral densities at each site were compared after adjusting for potential confounders, including age, sex, body mass index, smoking, alcohol consumption, and exercise.

RESULTS:

H. pylori infection was associated with a significant decrease in mean lumbar bone mineral density (H. pylori-positive, 1.190 g/cm2; H. pylori-negative, 1.219 g/cm2; P=0.006), which was greatest among men who were > or =50 years old (H. pylori-positive, 1.193 g/cm2; H. pylori-negative, 1.233 g/cm2; P=0.006). However, no significant association was observed in the bone mineral densities of the total femur and femoral neck.

CONCLUSION:

In men, H. pylori infection was negatively associated with lumbar bone mineral density. This association may be useful in the early detection, prevention, and management of male osteoporosis.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoporosis / Humo / Columna Vertebral / Consumo de Bebidas Alcohólicas / Ensayo de Inmunoadsorción Enzimática / Fumar / Absorciometría de Fotón / Índice de Masa Corporal / Densidad Ósea / Tamizaje Masivo Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Humanos / Masculino Idioma: Inglés Revista: Korean Journal of Family Medicine Año: 2015 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Osteoporosis / Humo / Columna Vertebral / Consumo de Bebidas Alcohólicas / Ensayo de Inmunoadsorción Enzimática / Fumar / Absorciometría de Fotón / Índice de Masa Corporal / Densidad Ósea / Tamizaje Masivo Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio de prevalencia / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Humanos / Masculino Idioma: Inglés Revista: Korean Journal of Family Medicine Año: 2015 Tipo del documento: Artículo