Meta-analysis of the effects of different lengths of orthokeratology on myopia in adolescents / 国际眼科杂志(Guoji Yanke Zazhi)

ABSTRACT

@#AIM: To systematically evaluate changes in dioptre, keratometry results, uncorrected visual acuity, and ocular axis in teenage patients with myopia using orthokeratology lens for different durations. To understand and determine the duration for using orthokeratology lens more accurately in these patients and to provide correct and reliable treatment guidance for these patients.<p>METHODS: Computerised search was conducted to retrieve studies from PubMed, CBM, WanFang Data, VIP, and CNKI databases, from the establishment of the databases to April 2019. The search yieldedrelevant studies on the use of orthokeratology to control the development of myopia in teenage patients. After two researchers independently conducted literature screening, data extraction, and methodological quality evaluation, a Meta-analysis was performed using RevMan 5.3 software.<p>RESULTS: Finally, 8 relevant studies were selected, which included 1 136 teenage patients with myopia. The Meta-analysis revealed that after wearing orthokeratology lens for 1wk, keratometry results changed without statistical significance \〖1wk <i>MD</i>=0.91, 95% <i>CI</i>(-0.01-1.83), <i>P</i>=0.05\〗. However, after using orthokeratology lens for 1, 3, 6, and 12mo, keratometry results decreased \〖1mo <i>MD</i>=0.82, 95% <i>CI</i>(0.12-1.53), <i>P</i>=0.02; 3mo <i>MD</i>=1.31, 95% <i>CI</i>(0.63-2.00), <i>P</i><0.05; 6mo <i>MD</i>=1.35, 95% <i>CI</i>(0.62-2.09), <i>P</i><0.05; 12mo <i>MD</i>=1.41, 95% <i>CI</i>(0.68-2.41), <i>P</i><0.05\〗. Further, after 12mo of using orthokeratology lens, the increase in dioptre was effectively controlled \〖12mo <i>MD</i>=2.61, 95% <i>CI</i>(1.52-3.71), <i>P</i><0.05\〗, and the uncorrected visual acuity improved \〖12mo <i>MD</i>=-0.81, 95% <i>CI</i>(-0.84--0.79), <i>P</i><0.05). The ocular axis did not show a statistically significant increase \〖12mo <i>MD</i>=-0.06, 95% <i>CI</i>(-0.21-0.09), <i>P</i>=0.44\〗. <p>CONCLUSION: The use of orthokeratology lens cannot only reducekeratometry values, but also control the growth of the ocular axis. However, these results can be achieved only after long-term wear.