The dark side of browning
Protein & Cell
; (12): 152-163, 2018.
Article
en En
| WPRIM
| ID: wpr-756957
Biblioteca responsable:
WPRO
ABSTRACT
The induction of brown-like adipocyte development in white adipose tissue (WAT) confers numerous metabolic benefits by decreasing adiposity and increasing energy expenditure. Therefore, WAT browning has gained considerable attention for its potential to reverse obesity and its associated co-morbidities. However, this perspective has been tainted by recent studies identifying the detrimental effects of inducing WAT browning. This review aims to highlight the adverse outcomes of both overactive and underactive browning activity, the harmful side effects of browning agents, as well as the molecular brake-switch system that has been proposed to regulate this process. Developing novel strategies that both sustain the metabolic improvements of WAT browning and attenuate the related adverse side effects is therefore essential for unlocking the therapeutic potential of browning agents in the treatment of metabolic diseases.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Tejido Adiposo Pardo
/
Envejecimiento
/
Biología Celular
/
Tejido Adiposo Blanco
/
Adipocitos Beige
/
Metabolismo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Protein & Cell
Año:
2018
Tipo del documento:
Article