Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer
Protein & Cell
;
(12): 141-151, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-757156
ABSTRACT
Gastric cancer is one of the most common malignancies worldwide; however, the molecular mechanism in tumorigenesis still needs exploration. BCL2L11 belongs to the BCL-2 family, and acts as a central regulator of the intrinsic apoptotic cascade and mediates cell apoptosis. Although miRNAs have been reported to be involved in each stage of cancer development, the role of miR-24 in GC has not been reported yet. In the present study, miR-24 was found to be up-regulated while the expression of BCL2L11 was inhibited in tumor tissues of GC. Studies from both in vitro and in vivo shown that miR-24 regulates BCL2L11 expression by directly binding with 3'UTR of mRNA, thus promoting cell growth, migration while inhibiting cell apoptosis. Therefore, miR-24 is a novel onco-miRNA that can be potential drug targets for future clinical use.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Neoplasias Gástricas
/
Secuencia de Bases
/
Regulación hacia Abajo
/
Movimiento Celular
/
Proteínas Proto-Oncogénicas
/
Apoptosis
/
Silenciador del Gen
/
MicroARNs
/
Línea Celular Tumoral
Límite:
Animales
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2016
Tipo del documento:
Artículo
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