Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis
Protein & Cell
;
(12): 173-181, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-757284
ABSTRACT
Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a hallmark of the development of atherosclerosis. Lipid homeostasis, especially cholesterol homeostasis, plays a crucial role during the formation of foam cells. Recently, lipid droplet-associated proteins, including PAT and CIDE family proteins, have been shown to control the development of atherosclerosis by regulating the formation, growth, stabilization and functions of lipid droplets in macrophage-derived foam cells. This review focuses on the potential mechanisms of formation of macrophage-derived foam cells in atherosclerosis with particular emphasis on the role of lipid homeostasis and lipid droplet-associated proteins. Understanding the process of foam cell formation will aid in the future discovery of novel therapeutic interventions for atherosclerosis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Aciltransferasas
/
Colesterol
/
Biología Celular
/
Receptores Activados del Proliferador del Peroxisoma
/
Alergia e Inmunología
/
Aterosclerosis
/
Proteínas Reguladoras de la Apoptosis
/
Proteínas de Unión a los Elementos Reguladores de Esteroles
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2012
Tipo del documento:
Artículo
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