Converted neural cells: induced to a cure?
Protein & Cell
;
(12): 91-97, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-757295
ABSTRACT
Many neurodegenerative disorders such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many groups were able to generate neural cells, either differentiated from induced pluripotent stem cells (iPSCs) or converted from somatic cells. Advances in converted neural cells have opened a new era to ease applications for modeling diseases and screening drugs. In addition, the converted neural cells also hold the promise for cell replacement therapy (Kikuchi et al., 2011; Krencik et al., 2011; Kriks et al., 2011; Nori et al., 2011; Rhee et al., 2011; Schwartz et al., 2012). Here we will mainly discuss most recent progress on using converted functional neural cells to treat neurological diseases and highlight potential clinical challenges and future perspectives.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson
/
Terapéutica
/
Trasplante
/
Accidente Cerebrovascular
/
Biología Celular
/
Transdiferenciación Celular
/
Células Madre Pluripotentes Inducidas
/
Tratamiento Basado en Trasplante de Células y Tejidos
/
Esclerosis Amiotrófica Lateral
/
Neuronas
Límite:
Animales
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2012
Tipo del documento:
Artículo
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