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Overexpression of sigma-1 receptor inhibits ADAM10 and ADAM17 mediated shedding in vitro
Protein & Cell ; (12): 153-159, 2012.
Artículo en Inglés | WPRIM | ID: wpr-757300
ABSTRACT
The sigma-1 receptor is a molecular chaperone protein highly enriched in the brain. Recent studies linked it to many diseases, such as drug addition, Alzheimer's disease, stroke, depression, and even cancer. Sigma-1 receptor is enriched in lipid rafts, which are membrane microdomains essential in signaling processes. One of those signaling processes is ADAM17- and ADAM10-dependent ectodomain shedding. By using an alkaline phosphatase tagged substrate reporter system, we have shown that ADAM10-dependent BTC shedding was very sensitive to both membrane lipid component change and sigma-1 receptor agonist DHEAS treatment while ADAM17-dependent HB-EGF shedding was not; and overexpression of sigma-1 receptor diminished ADAM17- and ADAM10-dependent shedding. Our results indicate that sigma-1 receptor plays an important role in modifying the function of transmembrane proteases.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Expresión Génica / Chlorocebus aethiops / Receptores sigma / Células COS / Microdominios de Membrana / Péptidos y Proteínas de Señalización Intercelular / Proteínas ADAM / Secretasas de la Proteína Precursora del Amiloide / Células HEK293 / Betacelulina Límite: Animales / Humanos Idioma: Inglés Revista: Protein & Cell Año: 2012 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Expresión Génica / Chlorocebus aethiops / Receptores sigma / Células COS / Microdominios de Membrana / Péptidos y Proteínas de Señalización Intercelular / Proteínas ADAM / Secretasas de la Proteína Precursora del Amiloide / Células HEK293 / Betacelulina Límite: Animales / Humanos Idioma: Inglés Revista: Protein & Cell Año: 2012 Tipo del documento: Artículo