DNA sensor cGAS-mediated immune recognition
Protein & Cell
;
(12): 777-791, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-757365
ABSTRACT
The host takes use of pattern recognition receptors (PRRs) to defend against pathogen invasion or cellular damage. Among microorganism-associated molecular patterns detected by host PRRs, nucleic acids derived from bacteria or viruses are tightly supervised, providing a fundamental mechanism of host defense. Pathogenic DNAs are supposed to be detected by DNA sensors that induce the activation of NFκB or TBK1-IRF3 pathway. DNA sensor cGAS is widely expressed in innate immune cells and is a key sensor of invading DNAs in several cell types. cGAS binds to DNA, followed by a conformational change that allows the synthesis of cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) from adenosine triphosphate and guanosine triphosphate. cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon production. Here we describe recent progresses in DNA sensors especially cGAS in the innate immune responses against pathogenic DNAs.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Unión Proteica
/
ADN Bacteriano
/
ADN Viral
/
Transducción de Señal
/
Interferón Tipo I
/
Modelos Moleculares
/
Regulación de la Expresión Génica
/
FN-kappa B
/
Proteínas Serina-Treonina Quinasas
/
Alergia e Inmunología
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2016
Tipo del documento:
Artículo
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