Omic studies reveal the pathogenic lipid droplet proteins in non-alcoholic fatty liver disease
Protein & Cell
;
(12): 4-13, 2017.
Artículo
en Inglés
| WPRIM
| ID: wpr-757375
ABSTRACT
Non-alcoholic fatty liver disease (NAFLD) is an epidemic metabolic condition driven by an underlying lipid homeostasis disorder. The lipid droplet (LD), the main organelle involved in neutral lipid storage and hydrolysis, is a potential target for NAFLD therapeutic treatment. In this review, we summarize recent progress elucidating the connections between LD-associated proteins and NAFLD found by genome-wide association studies (GWAS), genomic and proteomic studies. Finally, we discuss a possible mechanism by which the protein 17β-hydroxysteroid dehydrogenase 13 (17β-HSD13) may promote the development of NAFLD.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Genómica
/
Proteómica
/
Metabolismo de los Lípidos
/
Estudio de Asociación del Genoma Completo
/
Gotas Lipídicas
/
Enfermedad del Hígado Graso no Alcohólico
/
Genética
/
17-Hidroxiesteroide Deshidrogenasas
/
Metabolismo
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2017
Tipo del documento:
Artículo
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