Regulation of TAZ in cancer
Protein & Cell
;
(12): 548-561, 2016.
Artículo
en Inglés
| WPRIM
| ID: wpr-757407
ABSTRACT
TAZ, a transcriptional coactivator with PDZ-binding motif, is encoded by WWTR1 gene (WW domain containing transcription regulator 1). TAZ is tightly regulated in the hippo pathway-dependent and -independent manner in response to a wide range of extracellular and intrinsic signals, including cell density, cell polarity, F-actin related mechanical stress, ligands of G protein-coupled receptors (GPCRs), cellular energy status, hypoxia and osmotic stress. Besides its role in normal tissue development, TAZ plays critical roles in cell proliferation, differentiation, apoptosis, migration, invasion, epithelial-mesenchymal transition (EMT), and stemness in multiple human cancers. We discuss here the regulators and regulation of TAZ. We also highlight the tumorigenic roles of TAZ and its potential therapeutic impact in human cancers.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Presión Osmótica
/
Patología
/
Estrés Mecánico
/
Factores de Transcripción
/
Diferenciación Celular
/
Apoptosis
/
Proliferación Celular
/
Metabolismo Energético
/
Transición Epitelial-Mesenquimal
/
Genética
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2016
Tipo del documento:
Artículo
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