A loop matters for FTO substrate selection
Protein & Cell
;
(12): 616-620, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-757427
ABSTRACT
Recent studies have unequivocally established the link between FTO and obesity. FTO was biochemically shown to belong to the AlkB-like family DNA/RNA demethylase. However, FTO differs from other AlkB members in that it has unique substrate specificity and contains an extended C-terminus with unknown functions. Insight into the substrate selection mechanism and a functional clue to the C-terminus of FTO were gained from recent structural and biochemical studies. These data would be valuable to design FTO-specific inhibitors that can be potentially translated into therapeutic agents for treatment of obesity or obesity-related diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Especificidad por Sustrato
/
ADN
/
ARN
/
Proteínas
/
Clasificación
/
Dominio Catalítico
/
Secuencias de Aminoácidos
/
Enzimas Reparadoras del ADN
/
Histona H2a Dioxigenasa, Homólogo 1 de AlkB
/
Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2010
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS